Putnam, Seattle Gastroenterology Associates, Seattle; E. Quintero-Carrion, Hospital Universitario De Canarias Tenerife, Santa Cruz de Tenerife, Spain; J.P. Raufman, V. Raj, University of Arkansas for Medical Sciences, Little Rock; D.K. ); the Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill (R.S.S. var parentWidth = "324"; Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery. Incidence of Nonadjudicated Cardiovascular Adverse Events. LE RELIQUIE The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. © 2019 - Il Nuovo Torrazzo - All Rights Reserved - Powered by. Lane, Auckland City Hospital, Auckland, New Zealand; T.R. Maiza, Hospital Jose Joaquin Aguirre, Santiago, Chile; N.E. setTimeout(function () { bsaProContainer.fadeIn(); }, number_show_ads * 1000); Cardiovascular thrombotic events in controlled, clinical trials of rofecoxib. var parentHeight = "250"; The end point used in the Antiplatelet Trialists' Collaboration (APTC) study23 was also analyzed: the combined incidence of death from cardiovascular, hemorrhagic, and unknown causes; nonfatal myocardial infarction; and nonfatal ischemic and hemorrhagic stroke. NEW! Thrombotic events included fatal and nonfatal myocardial infarction, unstable angina, sudden death from cardiac causes, fatal and nonfatal ischemic stroke, transient ischemic attack, peripheral arterial thrombosis, peripheral venous thrombosis, and pulmonary embolism. Proc Natl Acad Sci U S A 1999;96:272-277, 26. Also, the relative risk in the rofecoxib group as compared with the placebo group was 6.10 among patients with a history of diabetes (95 percent confidence interval, 1.36 to 56.1), in contrast to a relative risk of 1.55 among patients with no history of diabetes (95 percent confidence interval, 0.92 to 2.61; P for interaction = 0.091). Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. J Am Coll Cardiol 2004;43:519-525, 4. Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism. animateThumb.height(parentHeight * scale); The content of this site is intended for health care professionals. In aggregate, previous randomized, controlled trials comparing rofecoxib with placebo or conventional NSAIDs other than naproxen have not demonstrated an increased cardiovascular risk associated with rofecoxib use. Morton, Queen Elizabeth Hospital, Edgbaston, United Kingdom; T.J. Myrhoj, J.R. Andersen, Hvidovre Hospital, Hvidovre, Denmark; A. Nakad, Hospital Notre Dame, Tournai, Belgium; V. Narayen, Gastrointestinal Diagnostic Center, Baltimore; Y. Niv, Rabin Medical Center, Petah Tikva, Israel; P.M. Pardoll, S. Scheinert, Center for Digestive Diseases, St. Petersburg, Fla.; C. Phino, J.M. Among patients with a history of colorectal adenomas, the use of rofecoxib was associated with an increased cardiovascular risk. Only the 1000 most recent citing articles are listed here. } var scale = objectWidth / parentWidth; var objectWidth = object.width(); $(document).ready(function(){ var js, fjs = d.getElementsByTagName(s)[0]; Guess HA, Lydick EG, Small RD, Miller LP. Batra, Henry Ford Hospital, Detroit; E. Bruun, J. Christiansen, Amtssygehuset i Herlev, Herlev, Denmark; C. Burke, Cleveland Clinic Foundation, Cleveland; E. Butruk, Akademia Medyczna w Warszawie, Warsaw; L. Capurso, Azienda Ospedaliera San Filippo, Rome; J.P. Cello, San Francisco General Hospital, San Francisco; S. Chaussade, Hospital Cochin Saint-Jacques, Paris; D.P. URP - Ufficio Relazioni col Pubblico var sid = "5"; This article was published at www.nejm.org on February 15, 2005. CAPITALE SOCIALE Euro 100.000,00 i.v. Solomon SD, McMurray JJV, Pfeffer MA, et al. The Adenomatous Polyp Prevention on Vioxx (APPROVe) Trial was designed to evaluate the hypothesis that three years of treatment with rofecoxib would reduce the risk of recurrent adenomatous polyps among patients with a history of colorectal adenomas. ); Merck Research Laboratories, West Point, Pa. Bresalier, A.A. Dekovich, T. Ben-Menachem, S.K. A total of 46 patients in the rofecoxib group had confirmed (i.e., adjudicated) thrombotic events during 3059 patient-years of follow-up (1.50 events per 100 patient-years), and 26 patients in the placebo group had such events during 3327 patient-years of follow-up (0.78 event per 100 patient-years). var innerThumb = $(".bsaProContainer-" + sid + " .bsaProItemInner__thumb"); function bsaProResize() { }); Enrollment occurred from February 2000 to November 2001 at 108 centers in 29 countries. Venne scelto come patrono dalla comunità civile cremasca dopo la sua misteriosa apparizione sulla città per liberarla dalla pestilenza il 10 giugno 1361. An independent, external safety-monitoring board met periodically to review safety data provided by a statistician who was aware of patients' study-group assignments. })(jQuery); (function(d, s, id) { Turgeon, University of Michigan, Ann Arbor; S.W. Un santo orientale, di Nicomedia (nell'attuale Turchia), il cui nome originario è Panteleimone che significa Misericordioso verso tutti. A recent case–control study27 suggested that the odds of nonfatal myocardial infarction differ between patients who take rofecoxib and those who take celecoxib, and a nested case–control study20 also suggested that there are differences in the risk of serious coronary heart disease between the two agents. object.height(parentHeight); var number_hide_ads = "0"; Incidence of Adjudicated Thrombotic Adverse Events. setTimeout(function () { bsaProContainer.fadeIn(); }, number_show_ads * 1000); The proportion of subjects taking low-dose aspirin at enrollment was capped at 20 percent because of the possible chemopreventive effects of the drug.22 Exclusion criteria were evidence of uncontrolled hypertension (defined by a blood pressure of more than 165/95 mm Hg); angina or congestive heart failure, with symptoms evoked by minimal activity; myocardial infarction, coronary angioplasty, or coronary-artery bypass grafting within the preceding year; or stroke or transient ischemic attack within two years before screening. Circulation 2001;104:2280-2288, 5. The possibility that conventional NSAIDs may have similar effects also has to be considered. STASERA ALLE 21 IL PONTIFICALE IN CATTEDRALE PRESIEDUTO DAL VESCOVO DANIELE. Oggi è la solennità del patrono di Crema, san Pantaleone, medico e martire. Ha subito il martirio nel 305 sotto l'imperatore Galerio. Il Martirologio romano fissa per la memoria di san Pantaleone la data del 27 luglio. DOI: 10.1056/NEJMoa050493, Tap into groundbreaking research and clinically relevant insights. Kim, University of Chicago Medical Center, Chicago; P. Knoflach, AKH Barmherzige, Schwestern vom heiligen Kreuz, Wels, Austria; M. Koch, Capital Gastroenterology Consultants, Silver Spring, Md. A total of 121 patients had investigator-reported serious thrombotic events (77 in the rofecoxib group and 44 in the placebo group). handcrafted in mexico. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. }); Movimento per la vita – La vita umana, un valore essenziale…. Rofecoxib is a selective COX-2 inhibitor that has been shown to be associated with significantly fewer gastrointestinal adverse events than NSAIDs. Prepare to become a physician, build your knowledge, lead a health care organization, and advance your career with NEJM Group information and services. E nel grande ciclo di affreschi della chiesa di S. Angelo in Formis a Capua, chiesa costruita da Desiderio, abate di Montecassino, poi papa Vittore III negli anni 1072-87, Johanson, Rockford Gastroenterology Associates, Rockford, Ill.; P.W. Via Aldo Moro n.15 var innerThumb = $(".bsaProContainer-" + sid + " .bsaProItemInner__thumb"); if ( number_show_ads > 0 ) { Indiano deferito, Cremasco – Droga nascosta in bottiglia con doppio fondo, 30enne nuovamente…, Prefettura – Spostamenti da Comune a Comune consentiti per…, Dovera – Infortunio sul lavoro, 18enne in ospedale, GIORNATA DELLA PREMATURITÀ – Il balcone del Comune s’illumina di viola, COVID-19 – Piloni (Pd): “Rimborso totale a Rsa e Rsd, ma…, A breve partiranno i lavori di ristrutturazione al bocciodromo di Crema, TAVOLO STRATEGICO – Avviato anche per il socio sanitario per strategie…, Lutto in Comune per la prematura scomparsa di Davide Fusar Bassini, Palazzo Pignano – “Insieme per la Pieve”: rassegna rinviata in attesa…, CORONAVIRUS – I dati del 17 novembre: +8.448 casi in regione,…, Bagnolo Cremasco – Autunno di grandi lavori pubblici in paese: riqualificazione,…, Coronavirus – I dati di oggi in Lombardia: +14.231 guariti-dimessi e…, Madignano – Guerrini Rocco torna ai Servizi sociali. Quan, Oxenius, Horgan, and Lines and Mr. Bolognese own equity in the company. Blood-pressure effects were seen by four weeks and remained relatively constant throughout the study. Lancet 2004;364:675-684, 17. var bsaProContainer = $('.bsaProContainer-7'); It was unclear how much of the increase in risk was due to a deleterious effect of high-dose rofecoxib, a protective effect of naproxen, chance, or a combination of these factors.26 A recent meta-analysis21 suggested that the magnitude of any cardioprotective effect of naproxen is unlikely to account entirely for these findings. var object = $(".bsaProContainer-" + sid + " .bsaProItemInner__img"); var objectWidth = object.width(); (H.Q., J.A. }); A high cardiovascular risk was defined by a history of symptomatic atherosclerotic cardiovascular disease or the presence of at least two of the following risk factors for coronary artery disease: a history of hypertension, a history of hypercholesterolemia, a history of diabetes, or current cigarette use. Comparison of cardiovascular thrombotic events in patients with osteoarthritis treated with rofecoxib versus nonselective nonsteroidal anti-inflammatory drugs (ibuprofen, diclofenac, and nabumetone). var number_hide_ads = "0"; Am J Cardiol 2002;90:959-963, 12. L’imperatore avrebbe voluto risparmiarlo e cercò di persuaderlo ad abiurare. Nel 1486, in occasione del prolungamento del coro del Duomo, demolendosi l'altare, fu trovata una cassettina d'avorio, ora scomparsa, piena di reliquie, tra le quali una parte del cranio di S. Pantaleone. bsaProResize(); Basic biology and clinical application of specific cyclooxygenase-2 inhibitors. Patients who took at least 80 percent of their tablets during the placebo run-in period were randomly assigned to receive either one 25-mg tablet of rofecoxib per day (the maximal recommended long-term daily dose) or one identical-appearing placebo tablet per day for three years. var parentHeight = "600"; No formal stopping rule was specified for terminating the study. patrÓn, its trade dress and the bee logo are trademarks. }(document, 'script', 'facebook-jssdk')); ANTENNA 5 SRL Società a Socio Unico ED. The following persons and institutions participated in the APPROVe Trial: Steering Committee — J.A. Arch Intern Med 2002;162:1099-1104, 7. We report on the cardiovascular outcomes associated with the use of the selective COX-2 inhibitor rofecoxib in a long-term, multicenter, randomized, placebo-controlled, double-blind trial designed to determine the effect of three years of treatment with rofecoxib on the risk of recurrent neoplastic polyps of the large bowel in patients with a history of colorectal adenomas. Am J Ther 2001;8:85-95[Erratum, Am J Ther 2001;8:220. Possible cardiovascular effects will need to be taken into account in an assessment of the potential ability of any of these drugs to prevent neoplasia in the large bowel and other organs. Egan KM, Wang M, Lucitt MB, et al. mechanical or electronic components, such as sensors; in this context, ambient intelligence and ubiquitous computing are envisioned to provide high-quality services, e.g., remote healthcare , to the human participants, i.e. For confirmed serious thrombotic events and the APTC end point, event rates were determined and relative risks (with 95 percent confidence intervals) were calculated with the use of Cox proportional-hazards models. The three most common adverse events resulting in the discontinuation of treatment were hypertension (25 patients in the rofecoxib group and 7 patients in the placebo group), increased blood pressure (6 in the rofecoxib group and 1 in the placebo group), and peripheral edema (7 in the rofecoxib group and 1 in the placebo group). Pantaleone, o anche Pantaleo (in greco: Παντελεήμων, Panteleimon; Nicomedia, … – Nicomedia, 27 luglio 305), è stato un santo greco antico. ); the Department of Medicine, Clinic University Hospital, Zaragoza, Spain (A.L. San Pantaleone è pure nella tradizione liturgica milanese, che celebrava il martire di Nicomedia nel suo calendario al 10 giugno: Crema fu sottomessa a Milano dal 1335 al 1449 e da Milano la tradizione cristiana di Crema ricevette la nuova data della celebrazione della festa, rispetto a quella universale del 27 luglio. Swaim, Regional Research Institute, Jackson, Tenn.; J.C. Wolper, P.L. Il Nuovo Torrazzo, tramite la Fisc (Federazione Italiana Settimanali Cattolici), ha aderito allo IAP (Istituto dell’Autodisciplina Pubblicitaria) accettando il Codice di Autodisciplina della Comunicazione Commerciale. Potential thromboembolic events, components of the APTC end point, and all deaths (regardless of cause) were prespecified as eligible for adjudication according to standard procedures for rofecoxib studies initiated by the sponsor in 1998. Un’urna è conservata presso un bellissimo santuario a lui dedicato a Borgo, frazione di Montoro Inferiore, completamente restaurato nel 2013. N Engl J Med 2005;352:1071-1080. Patients in the rofecoxib group had increases in systemic arterial pressure during the trial, a finding that is consistent with the previously reported renovascular effects of NSAIDs. 13 NOVEMBRE – La “Giornata Mondiale della Gentilezza”, ACCORDO CINA-UE – Salini (Fi-Ppe): “Bene riconoscimento Dop e Igp. setTimeout(function () { bsaProContainer.fadeOut(); }, number_hide_ads * 1000); Ha subito il martirio nel 305 sotto l'imperatore Galerio. }); Se continui ad utilizzare questo sito supponiamo che tu ne sia felice. There were no significant interactions between treatment group and subgroups (P>0.10 for all comparisons) for confirmed serious thrombotic events in subgroup analyses based on country (United States vs. other); age; sex; use or nonuse of antihypertensive drugs at baseline, low-dose aspirin at baseline, or low-dose aspirin for more than 50 percent of follow-up; presence or absence of a history of hypertension, hypercholesterolemia, or ischemic heart disease; presence or absence of current cigarette use; or presence or absence of a high cardiovascular risk. Patients were evaluated clinically at randomization and at weeks 4, 17, 35, 52, 69, 86, 104, 121, 138, 156, and 158 or after the discontinuation of treatment. Mamdani M, Juurlink DN, Lee DS, et al. Così nacquero le ampolle (molto più piccole) custodite a Costantinopoli, Montauro, Martignano, Caiazzo, nella chiesa del Santissimo Salvatore all’Immacolata di Irsina e nel monasterio de la Encarnación di Madrid. Other investigator-reported cardiovascular events known to be associated with NSAID use, such as congestive heart failure and pulmonary edema, although less well defined, occurred earlier (at approximately five months) and at a higher rate among patients taking rofecoxib than among those taking placebo. Circulation 2005;111:334-342, 13. Information, resources, and support needed to approach rotations - and life as a resident. Soares, Celestial Ordem Terceira da Santissima, Porto, Portugal; I. Pokorny, Prerov, Czech Republic; J. Ponce-Garcia, Hospital Universitari La Fe Valencia, Valencia, Spain; T. Ponchon, Hospital Edouard Herriot, Lyon, France; J.H. Per continuare la navigazione dovrai accettare la nostra polita cookies, Crema – Uomo travolto da un treno in transito, tragedia in…, Crema – “Sono stato rapinato”, ma è tutta un’invenzione. From the Department of Gastrointestinal Medicine and Nutrition, University of Texas M.D. Bolognese, B.O., K.H., C.L. Kaplan–Meier Estimates of the Cumulative Incidence of Investigator-Reported Congestive Heart Failure (CHF), Pulmonary Edema (PE), or Cardiac Failure (CF). Vital signs, including blood pressure obtained while the patient was seated, were measured at each clinic visit during the study according to the usual clinical practice. Il Nuovo Torrazzo fruisce dei contributi statali diretti di cui alla Legge 7 agosto 90 n. 250. innerThumb.height(parentHeight); $(window).resize(function(){ object.height(parentHeight); ; W. Harford, Veterans Affairs Medical Center, Dallas; S.M. var scale = objectWidth / parentWidth; } else { Van der Merwe, Pretoria, South Africa; R. VanStolk, C.W. Hultcrantz, Karolinska Universitetssjukhuset-Solna, Stockholm; S.H. Several exploratory analyses were performed to delineate the relation between mean arterial pressure and the study findings. } There was earlier separation (at approximately five months) between groups in the incidence of nonadjudicated investigator-reported congestive heart failure, pulmonary edema, or cardiac failure (hazard ratio for the comparison of the rofecoxib group with the placebo group, 4.61; 95 percent confidence interval, 1.50 to 18.83). Harris, N.B. A total of 3260 patients were screened for the study, of whom 2586 were deemed to be eligible; 1287 of the eligible patients were randomly assigned to receive rofecoxib, and 1299 to receive placebo (Figure 1). Baron (chair), R.S. The increased relative risk became apparent after 18 months of treatment; during the first 18 months, the event rates were similar in the two groups. $(document).ready(function(){ Le reliquie del Santo Patrono custodite a Crema, in Duomo, sono due. This was accomplished by evaluating the interaction between the logarithm of time and the assigned treatment in the Cox proportional-hazards model. The procedure for confirming cardiovascular events was prespecified in the protocol. var number_hide_ads = "0"; Lancet 2004;364:2021-2029, 22. McQuaid, Veterans Affairs Medical Center, San Francisco; G. Minoli, Ospedale Valduce Reparto, Como, Italy; M. Montoro, Hospital San Jorge, Huesca, Spain; A. Montoya, Clinica Shaio, Bogota, Colombia; G. Morelli, Optimum Clinical Research, Montreal; D.G. Arch Intern Med 2003;163:481-486, 19. Fitzgerald GA, Patrono C. The coxibs, selective inhibitors of cyclooxygenase-2. Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery. È certamente la domanda che ancora oggi i Cremaschi si pongono. Holt, Endoscopic Microsurgery Associates, Towson, Md. Analysis of a database including 5435 patients with osteoarthritis in eight double-blind, placebo-controlled, phase 2B or phase 3 trials reported similar rates of thrombotic cardiovascular adverse events with rofecoxib, placebo, and various nonselective NSAIDs.5 A pooled analysis of data from more than 28,000 patients with various diseases (representing more than 14,000 patient-years at risk) from 23 previous trials of rofecoxib (phase 2B through phase 5), including patients from the VIGOR trial, also did not demonstrate a significant increase in cardiovascular risk for rofecoxib as compared with placebo or NSAIDs other than naproxen.4 This analysis used the APTC end point we evaluated. A randomized trial of aspirin to prevent colorectal adenomas. S. Pantaleone occupa un posto di particolare dignità. var bsaProContainer = $('.bsaProContainer-13'); Baerg, Tacoma Digestive Disease Center, Tacoma, Wash.; H. Baistrocchi, Unidad de Aparato Digestivo Julio Dante Baistrocchi, Cordoba, Argentina; M.L. Ann Intern Med 2005;142:157-164, 28. Dr. Baron also reports having served as an unpaid consultant to Bayer. ); the Department of Medicine, Tufts–New England Medical Center, Boston (M.A.K. Provenza, Louisiana Research Center, Shreveport; W.S. } Overall and cardiovascular mortality was similar in the two groups. Cucchiara, Rita; Grana, Costantino "Using the Topological Tree for skin lesion structure description" Knowledge-based Intelligent Information Engineering Systems & Allied Technologies, Podere d'Ombriano, Crema, Italy, pp. COX-2 inhibitors have been widely used as antiinflammatory and pain-relief agents and may hold promise as chemopreventive agents for a variety of epithelial cancers.
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